2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-158949
    1-Palmitoyl-2-11(Z)-octadecenoyl-3-oleoyl-rac-glycerol 2692623-16-6 98%
    1-Palmitoyl-2-11(Z)-octadecenoyl-3-oleoyl-rac-glycerol (1-Palmitolein-2-(11Z)-octadecenoin-3-olein) is a triacylglycerol that contains Palmitic acid (HY-N0830), cis-Vaccenic acid (HY-113427A), and Oleic acid (HY-N1446).
    1-Palmitoyl-2-11(Z)-octadecenoyl-3-oleoyl-rac-glycerol
  • HY-158951
    C24 (2'(S)-Hydroxy) phytoceramide (t18:0/24:0) 154801-34-0 98%
    C24 (2'(S)-Hydroxy) phytoceramide (t18:0/24:0) is a ceramide.
    C24 (2'(S)-Hydroxy) phytoceramide (t18:0/24:0)
  • HY-158957
    1,3-Diheptadecanoyl-2-oleoyl glycerol 869990-15-8 98%
    1,3-Diheptadecanoyl-2-oleoyl glycerol (1,3-Heptadecanoin-2-olein) is a triacylglycerol that contains Heptadecanoic acid (HY-W004284) and Oleic acid (HY-N1446).
    1,3-Diheptadecanoyl-2-oleoyl glycerol
  • HY-158958
    1,2-Dilinoleoyl-3-γ-linolenoyl-rac-glycerol 852369-68-7 98%
    1,2-Dilinoleoyl-3-γ-linolenoyl-rac-glycerol (1,2-Linolein-3-γ-linolenin) is a triacylglycerol that contains Linoleic acid (HY-N0729) and Gamma-Linolenic acid (HY-N7140).
    1,2-Dilinoleoyl-3-γ-linolenoyl-rac-glycerol
  • HY-158959
    1,3-Diarachidonoyl-2-oleoyl glycerol 869990-37-4 98%
    1,3-Diarachidonoyl-2-oleoyl glycerol (1,3-Diarachidonin-2-olein) is a triacylglycerol that contains Arachidic acid (HY-W004260) and Oleic acid (HY-N1446).
    1,3-Diarachidonoyl-2-oleoyl glycerol
  • HY-158960
    1,2-Dioleoyl-3-arachidonoyl-rac-glycerol 91539-55-8 98%
    1,2-Dioleoyl-3-arachidonoyl-rac-glycerol (1,2-Olein-3-arachidonin) is a triacylglycerol that contains Oleic acid (HY-N1446) and Arachidonic acid (HY-109590).
    1,2-Dioleoyl-3-arachidonoyl-rac-glycerol
  • HY-158961
    1,3-Dielaidoyl-2-oleoyl glycerol 946577-28-2 98%
    1,3-Dielaidoyl-2-oleoyl glycerol (1,3-Elaidin-2-olein) is a triacylglycerol that contains Elaidic acid (HY-113016) and Oleic acid (HY-N1446).
    1,3-Dielaidoyl-2-oleoyl glycerol
  • HY-158964
    1-Palmitoyl-2-oleoyl-3-linolenoyl-rac-glycerol 78144-20-4 98%
    1-Palmitoyl-2-oleoyl-3-linolenoyl-rac-glycerol (1-Palmitin-2-olein-3-linolenin) is a triacylglycerol that contains Palmitic acid (HY-N0830), Oleic acid (HY-N1446), and α-Linolenic acid (HY-N0728).
    1-Palmitoyl-2-oleoyl-3-linolenoyl-rac-glycerol
  • HY-158987
    Adenosine phosphonobutyric, 2'(3'), 5'-diposphate 1050202-63-5 98%
    Adenosine phosphonobutyric, 2'(3'), 5'-diposphate (APBADP) is an adenylosuccinate lyase substrate analog and competitive inhibitor. Adenosine phosphonobutyric, 2'(3'), 5'-diposphate binds to the tetramers of *Bacillus subtilis* adenylosuccinate lyase and wild-type human adenylosuccinate lyase. Adenosine phosphonobutyric, 2'(3'), 5'-diposphate can be used for research on adenylosuccinate lyase deficiency.
    Adenosine phosphonobutyric, 2'(3'), 5'-diposphate
  • HY-159259
    cis-11,12-Methylenepentadecanoic acid 3027163-18-1 98%
    cis-11,12-Methylenepentadecanoic acid is a fatty acid.
    cis-11,12-Methylenepentadecanoic acid
  • HY-159260
    cis-13,14-Methyleneheptadecanoic acid 3027163-19-2 98%
    cis-13,14-Methyleneheptadecanoic acid is a fatty acid.
    cis-13,14-Methyleneheptadecanoic acid
  • HY-15981R
    Omarigliptin (Standard) 1226781-44-7 98%
    Omarigliptin (Standard) is the analytical standard of Omarigliptin. This product is intended for research and analytical applications. Omarigliptin (MK-3102) is a potent, selective, orally active and cross the blood-brain barrier dipeptidyl peptidase 4 (DPP-4) inhibitor. Omarigliptin shows anti-parkinsonian activity. Omarigliptin has the neuroprotective effect to improve diabetes-associated cognitive dysfunction.
    Omarigliptin (Standard)
  • HY-160003
    PPARγ agonist 9 474329-47-0 98%
    PPARγ agonist 9 is an agonist of PPARγ. PPARγ agonist 9 is the analogue of lysophosphatidic acid with an EC50 more than 10 μM for LPA3 receptor.
    PPARγ agonist 9
  • HY-160079
    3′-O-Azidomethyl-dCTP 1048021-94-8
    3′-O-Azidomethyl-dCTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3′-O-Azidomethyl-dCTP
  • HY-160204
    16:0 Cardiolipin disodium 64043-42-1 98%
    16:0 Cardiolipin (Diphosphatidylglycerol (16:0)) disodium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
    16:0 Cardiolipin disodium
  • HY-160212
    JP3000 3034097-74-7 98%
    JP3000, a chemical probe, is an agonist of RXRA, RXRB, RXRG.
    JP3000
  • HY-160281
    CCD-2 2271351-19-8 98%
    CCD-2 is a conventional detergent and is readily degraded. CCD-2 can efficiently solubilize and stabilize diverse G protein-coupled receptors (GPCRs). CCD-2 is amenable to the β-barrel protein research. The chemical cleavage of CCD-2 is rapid, complete and biorthogonal and should facilitate a chemical methodology for in situ detergent replacement in diverse membrane proteins (MPs) studies.
    CCD-2
  • HY-160431
    8(9)-EET 82864-43-5 98%
    8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. 8(9)-EET is an effective substrate for COX-1 and COX-2. 8(9)-EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate.
    8(9)-EET
  • HY-160456
    FABP4/5-IN-4 2862795-48-8 98%
    FABP4/5-IN-4 (compound E1) is a potent inhibitor of FABP4 and FABP5, with the IC50s of 3.78 μM and 5.72 μM, respectively. FABP4/5-IN-4 plays an important role in metabolism disorder like diabetes mellitus.
    FABP4/5-IN-4
  • HY-160475
    AD-9308 1804942-56-0 98%
    AD-9308 is a highly selective and orally active ALDH2 activator. AD-9308 activates ALDH2 to promote the clearance of 4-HNE, inhibiting myocardial fibrosis, inflammation and cell apoptosis. AD-9308 improves mitochondrial function, sarcoplasmic reticulum/ endoplasmic reticulum calcium transport and regulates autophagy, restoring intracellular homeostasis. AD-9308 improves the diastolic and systolic function of the heart in diabetic mice and reverses ventricular mal-reconstruction. AD-9308 can be used for the study of diabetic cardiomyopathy.
    AD-9308
Cat. No. Product Name / Synonyms Application Reactivity